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PoFink (cefpodoxime)

Cefpodoxime is an oral third generation cephalosporin antibiotics. It is active against most Gram positive and Gram negative organisms. Notable exceptions include Pseudomonas aeruginosa, Enterococcus and Bacteroides fragilis.  It is commonly used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea. It also finds use as oral continuation therapy when intravenous cephalosporins (such as ceftriaxone) are no longer necessary for continued treatment.

Cefpodoxime inhibits cell wall synthesis by inhibiting final transpeptidation step of peptidoglycan synthesis in cell walls. It has well established pharmacokinetic profile with absorption of 50%. It is indicated in Community Acquired Pneumonia, Uncomplicated Skin and Skin Structure Infections and Uncomplicated Urinary Tract Infections.

Currently, certain bacteria, such as Citrobacter amalonaticus. Enterobacter intermedius and Listeria innocua are resistant toward Cefpodoxime. While Haemophilus influenza, , Neisseria gonorrhea, Salmonella Agona and Shigella boydii are susceptible to Cefpodoxime. Some bacteria, such as Bacteroides bivius, Clostridium difficile, Escherichia coli and Klebsiella pneumonia have developed resistance towards Cefpodoxime to varying degrees.


Why is this medication prescribed?

Cefpodoxime is a cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, skin, throat, and urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Cefpodoxime comes as a tablet and liquid to take by mouth. It is usually taken every 12 hours (twice a day) for 7-14 days. A single dose is given to treat gonorrhea. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take cefpodoxime exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly.

The tablets should be swallowed whole and taken with a full glass of water.

Continue to take cefpodoxime even if you feel well. Do not stop taking cefpodoxime without talking to your doctor.

What special precautions should I follow?

Before taking cefpodoxime,

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Cefpodoxime may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

·         upset stomach

·         diarrhea

·         vomiting

·         mild skin rash

If you experience any of the following symptoms, call your doctor immediately:

·         severe skin rash

·         itching

·         hives

·         difficulty breathing or swallowing

·         wheezing

·         unusual bleeding or bruising

·         sore throat

·         painful mouth or throat sores

·         vaginal infection

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Keep liquid medicine in the refrigerator, tightly closed, and throw away any unused medication after 14 days. Do not freeze. Talk to your pharmacist about the proper disposal of your medication. 

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to cefpodoxime.

If you are diabetic, call your doctor before changing diet or dosage of medicine. Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms of infection after you finish the cefpodoxime, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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